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Less official than New York's borough delineations, San Francisco is composed of a patchwork of neighborhoods, each with its own unique flavor, feel, shops and vibe.

San Franciscans are opposed to the widespread appearance of chain stores or large mall complexes (save for the ultra-tourist suction cup of Union Square), thus every neighborhood is a unique composition of its own green grocers, independently owned hardware stores, cafes and restaurants and local businesses.
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For the Fun of it
A discriminating and well-read kind of traveler comes to San Francisco for a taste of the gold rush.
On a Budget
Staying downtown can be loud and bustling, especially if you're putting kids to bed early.
Around the Airport
If you need to catch an early flight, it may be a good idea to stay close to the airport the night before.
On the Road Again
If you're here to meet with clients, they're probably in the Financial District or South of Market (SoMa).
The More the Merrier
Staying downtown can be loud and bustling, especially if you're putting kids to bed early.
Singles Scene
College kids, recent grads, or anyone in this age group will have no shortage of neighborhoods to investigate.